with regions of reduced Fluorescence. The bronchial mucosa appears normal with conventional (white light) bronchoscopy, but on being illuminated in the fluorescent mode, emits a image idential to that of normal mucosa. The trachea and left-sided bronchial branches appear normal in the fluorescence mode, but distinct areas of reduced fluorescence can be observed on the right-sided bronchial tree (upper lobe spur, middle lobe spur, right main bronchus and RB 9/10 spur). Endoscopists using to the LIFE-System or SAFE 1000 for the first time can practice switching from white light to fluorescent mode, and in the latter mode, learn (light intensity) adjustment, in addition to recognizing areas of reduced fluorescence.